Today we started to look at glycolysis, step by step. We made it about half-way through the process, having broken a six-carbon species down into two equivalent three-carbon species. The "big-ticket" items that we saw included: the use of keto-enol tautomerism to "slide" a carbonyl down a carbon, a retro-aldol to break the six-carbon carbohydrate into two separate three-carbon species, the idea of oxidizing an aldehyde by adding a heteroatom nucleophile and then abstracting a hydride with NAD+, and the concept that all of this can also be done by attaching the molecule to an enzyme covalently through a lysine residue to form an imine.
We'll finish this off on Wednesday and then look at the reverse process.
The picture is of boxing legend "Sugar" Ray Robinson.
1 comment:
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