Fatty Acid synthesis

Yesterday we started to look at the process by which acetylCoA is converted to fatty acids (the reverse of the process that we had been studying). The major new process was the use of biotin-mediated reaction of ATP/bicarbonate/acetylCoA to transfer a carbon dioxide to acetylCoA and manufacture malonylCoA. We also saw that there were a number of transthioesterifications and the use of our friend NADH in a reduction, followed by an E1cb elimination. We'll finish this off tomorrow.